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Zatium (Brand name: Actos)

  • $0.38
  • Brand name: Actos
  • Availability: In Stock
  • Active Ingredient pioglitazone
Zatium (Pioglitazone) is used to control high blood sugar in type 2 diabetes (non-insulin-dependent diabetes mellitus).
Analogs of Zatium (Brand name: Actos): Actoplus Met   Duetact  
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Other names of Zatium (Brand name: Actos): a   b   c   d   e   f   g   h   i   j   k   l   m   n   o   p   q   r   s   t   u   v   w   x   y   z  
Accord Pioglitazone   Actomeg   Actose   Actosmet   Actozone   Adpas   Amaryl-P   Apo-Pioglitazone   Asoformin-P   Acpio   Actazone   ActoPlus met XR   Actos M   Actos Met   Actos OD   Anxotos   Zatium  
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30 mg
Product name Per Pill Per Pack  
30 pills $1.18 $35.33
60 pills $0.87 $70.66 $52.16
90 pills $0.77 $105.99 $68.99
120 pills $0.72 $141.32 $85.82
180 pills $0.66 $211.99 $119.48
270 pills $0.63 $317.98 $169.97
360 pills $0.61 $423.97 $220.46
45 mg
Product name Per Pill Per Pack  
30 pills $1.31 $39.22
60 pills $0.96 $78.43 $57.47
90 pills $0.84 $117.65 $75.73
120 pills $0.78 $156.86 $93.97
180 pills $0.72 $235.30 $130.48
240 pills $0.70 $313.73 $166.99
360 pills $0.67 $470.59 $240.01
15 mg
Product name Per Pill Per Pack  
60 pills $0.75 $45.05
90 pills $0.60 $67.58 $54.33
120 pills $0.53 $90.11 $63.61
180 pills $0.46 $135.16 $82.17
270 pills $0.41 $202.74 $110.03
360 pills $0.38 $270.32 $137.84

Product Description

Common use

Zatium is used to control high blood sugar in type 2 diabetes (non-insulin-dependent diabetes mellitus). This form of the illness is usually caused by inability of the body to respond correctly to insulin: either the body does not produce enough insulin or the cells ignore the insulin. Insulin is the natural hormone that helps to transfer sugar out of the blood and into the cells, where it is metabolized to energy. Zatium works by improving the response of the body to insulin, rather than increasing its insulin output. Zatium also reduces the production of unneeded sugar in the liver.
It is possible to use Zatium (and rosiglitazone maleate as well) alone or together with insulin injections or other oral diabetes medications such as glipizide, glyburide, metformin hydrochloride.

Dosage and directions

Take this medication by mouth, with or without food, usually one time a day. Follow all directions of your health care advisor as dosage is based on your medical condition, possible reaction to therapy, and can be corrected if you are treated by other anti-diabetic medications. Take this drug each time the same day as this way you will get the most benefit from it. Regularly monitor blood glucose levels. It may take up to 2 to 3 months before the full benefit is realized. Take all other medications for diabetes according to recommendations of your doctor.

Precautions

Before taking Zatium, tell your doctor or pharmacist if you are allergic to it; if you are allergic to other "glitazones" (such as rosiglitazone, troglitazone); or if you have any other types of allergy. Do not use Zatium if you have certain medical conditions. Before starting treatment with Zatium, notify you doctor or pharmacist if you have: type 1 diabetes (insulin-dependent diabetes), heart failure (acute congestive heart failure) either newly diagnosed or worsening, dangerously high blood glucose (diabetic ketoacidosis), liver dysfunctions. Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart disease (chronic congestive heart failure), liver problems, fluid in your lungs, swelling (edema), anemia. Extremely low or high blood sugar levels may cause blurred vision, dizziness, or drowsiness; be cautious engaging in activities requiring alertness for example driving or operating machinery. Limit alcohol as much as possible when you are treated with this medication because it can increase the risk of developing hypoglycemia. If you have fever, infection, injury or surgery, it may complicate controlling of your blood sugar. Consult your doctor, as you may need correction of dose or a change in your medication may be required. Women with certain fertility problems may have changes in the menstrual cycle (ovulation) taking this medication. Consult your doctor or pharmacist about prescription of reliable contraception while you are taking Zatium. This medication should be used in pregnant women only in life threating conditions. Discuss its risks and benefits with your physician. If you are pregnant your doctor may substitute insulin for Zatium. Follow all instructions carefully. There are no reports whether this drug excretes with breast milk. Breastfeeding is not advised while using this drug. Before starting breastfeeding consult your physician.

Possible side effects

Zatium side effects include rapid heartbeat, sweating, confusion, blurred vision, headache, numbness or tingling of the mouth, weakness,shakiness, dizziness, tiredness, paleness and sudden hunger.

Missed dose

If you miss a dose, take it as soon as you remember unless just a few hours remained till your next dose. Skip the missed dose and return to the dosing schedule in case it is near the time of the next dose. Do not double the dose to make up the dose you missed.

Overdose

Seek emergency medical attention if you think you have taken too much of this medicine. You may have signs of low blood sugar, such as hunger, weakness, dizziness, headache, irritability, drowsiness, fainting, sweating, confusion, tremors, fast heartbeat, seizure (convulsions), or coma.

Drug interactions

Inform your health care advisor if you are taking any other anti-diabetic medications (insulin, metformin, or sulfonylureas such as glyburide), herbal/natural products (fenugreek, ginseng, gymnema). This medication is able to decrease the effectiveness of certain contraceptives which may result in pregnancy. Take care about additional form of reliable birth control while using Zatium. Do not begin or discontinue an intake of any medicine without doctor or pharmacist approval.

Storage

Store at room temperature in a tight container, away from moisture and humidity.

Disclaimer 

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

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We employ only professional medical specialists, who are always ready to provide the necessary assistance and intake directions. Following the individually adjusted recommendations will minimize the risks of any abnormalities and development of side effects. Do not start the course until you are sure you have no contraindications or precautions for the drug use. The following side effects may appear if you misuse or overuse the medicine:

More Common

  • Chest pain
  • decreased urine output
  • dilated neck veins
  • extreme fatigue
  • irregular breathing
  • irregular heartbeat
  • problems with teeth
  • swelling of the face, fingers, feet, or lower legs
  • tightness in the chest
  • trouble breathing
  • weight gain
  • Blurred vision or other changes in vision
  • cough
  • dry mouth
  • flushed, dry skin
  • fruit-like breath odor
  • headache
  • increased hunger
  • increased thirst
  • increased urination
  • loss of consciousness
  • muscle pain or soreness
  • problems with your teeth
  • runny or stuffy nose
  • sore throat
  • stomachache
  • sweating
  • unexplained weight loss

Less Common

  • Pain or swelling in the arms or legs without an injury
  • pale skin
  • swelling
  • trouble with breathing when active
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Incidence Not Known

  • Dark urine
  • loss of appetite
  • nausea or vomiting
  • stomach pain
  • unexplained, rapid weight gain
  • yellow eyes or skin
Type Small Molecule
Accession Number DB01132  (APRD00653)
Groups Approved, Investigational
Synonyms
  • (+-)-5-((4-(2-(5-Ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione
  • 5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione
  • Pioglitazona
  • Pioglitazone
  • Pioglitazonum
UNII X4OV71U42S
CAS number 111025-46-8
Weight Average: 356.439
Monoisotopic: 356.119463206
Chemical Formula C19H20N2O3S
InChI
InChI=1S/C19H20N2O3S/c1-2-13-3-6-15(20-12-13)9-10-24-16-7-4-14(5-8-16)11-17-18(22)21-19(23)25-17/h3-8,12,17H,2,9-11H2,1H3,(H,21,22,23)
IUPAC Name
5-({4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl}methyl)-1,3-thiazolidine-2,4-dione
Protein binding

Pioglitazone is extensively protein bound (> 99%) in human serum, principally to serum albumin. Pioglitazone also binds to other serum proteins, but with lower affinity [Label].

Toxicity Not Available
Half life

The mean serum half-life of pioglitazone and its metabolites (M-III and M-IV) range from 3 to 7 hours and 16 to 24 hours, respectively [Label].

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  • Tunis
  • Sfax
  • Sousse
  • Ettadhamen
  • Kairouan
  • Gabès
  • Bizerte
  • Aryanah
  • Gafsa
  • El Mourouj